ABSTRACT
Purpose
The objective of this study is to compare the efficacies of 3 different intrathecal
doses (80, 120, and 160 mcg) of morphine in achieving postcesarean delivery analgesia
and the severity of the side effects thereof.
Design
A prospective, randomized, double-blind study.
Methods
A total of 150 pregnant women between the ages of 18 to 40, with a gestational week
>36, who were planned to have elective cesarean section were included in the study.
Patients were randomized into 3 groups based on the dosages of intrathecal doses of
morphine (80, 120, and 160 mcg) they will receive in addition to 10 mg 0.5% hyperbaric
bupivacaine and 20 mcg fentanyl. Intravenous (IV) patient-controlled analgesia (PCA)
prepared with fentanyl was administered to each patient after the surgery. Postoperative
24-hour total IV PCA-fentanyl consumption was recorded. The patients were evaluated
for side effects such as pain, nausea-vomiting, pruritus, sedation score, and respiratory
depression after the surgery.
Findings
PCA-fentanyl consumption was significantly higher in Group 1 compared to Group 2 and
3 (P = .047). There was no significant differences between the groups in terms of nausea-vomiting
scores. The pruritus scores were significantly higher in Group 3 compared to Group
1 (P = .020). The pruritus scores were significantly higher in all groups at the postoperative
8th-hour (P = .013). Respiratory depression, which would require treatment, was not observed
in any patient.
Conclusions
Based on the study findings, it was concluded that 120 mcg intrathecal morphine provides
adequate analgesia with minimal side effects in cesarean sections.
Keywords
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Article info
Publication history
Published online: March 28, 2023
Publication stage
In Press Corrected ProofFootnotes
Conflict of Interest: None to report.
Funding: This study was supported by Ondokuz Mayıs University with the project number PYO.TIP.1904.18.010.
Identification
Copyright
© 2022 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.
