Abstract
Purpose
Postoperative sore throat (POST) is a frequent postoperative complication. Pre-induction
budesonide inhalation is effective in POST prevention. However, it requires inhaler
equipment and patient cooperation. Budesonide spraying on the endotracheal (ETT) cuff
is simple and can be performed on most patients requiring endotracheal intubation.
This study aims to compare the effects of budesonide spray and K-Y gel as an ETT cuff
lubricant on the incidence and severity of POST.
Design
Randomized and triple-blinded study.
Methods
One hundred patients undergoing elective non-cardiac surgery were randomly allocated
into the budesonide group (n = 50) and the K-Y gel group (n = 50). In the budesonide
group, 200 mcg of budesonide was sprayed on the cuff of the ETT. For the K-Y gel group,
the ETT cuff was lubricated with K-Y gel. A visual analog scale was used to assess
the severity of POST at 2, 6, and 24 hours after surgery. Other complications of tracheal
intubation and adverse effects of budesonide were also recorded.
Findings
Compared to the K-Y gel group, the budesonide group had a significantly lower overall
incidence of POST (30% versus 54%, P = .032) and reduced the risk of POST by 24% (relative risk reduction = 24%, 95% CI,
5.23-42.77, P = .012) as well as the incidence of hoarseness (8.6% vs 34%, P = .001) and cough (0% vs 8%, P = 0.041). No incidence of drug-related side effects was reported in both groups.
Conclusions
Spraying budesonide on the ETT cuff significantly reduces the incidence and severity
of POST.
Keywords
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Article info
Publication history
Published online: January 05, 2023
Publication stage
In Press Corrected ProofFootnotes
Conflict of Interest: None to report.
Availability of Data and Materials: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Trial Registration: This research was retrospectively registered in the Thai Clinical Trials Registry (TCTR). This research was reviewed and approved by TCTR Committee on 13 January 2022. The TCTR identification number is TCTR20220113001.
Funding: The authors report no involvement in the research by the sponsor that could have influenced the outcome of this work.
Identification
Copyright
© 2022 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.
