ABSTRACT
Purpose
In our previous study, hypokalemia incidence was high in patients scheduled for laparoscopic
colorectal resection. This trial was conducted to verify the effects of preoperative
carbohydrate drinks containing potassium in these patients.
Design
A three-arm randomized controlled design was used.
Methods
Patients were randomly assigned to control, placebo, and treatment groups. In the
control group, patients fasted from midnight. In the placebo group, patients fasted
from midnight and received carbohydrate drinks 2 to 3 hours before surgery. In the
treatment group, patients fasted from midnight and received carbohydrate drinks containing
potassium supplementation 2 to 3 hours before surgery. The primary outcome was the incidence and severity of preoperative hypokalemia. Other
outcomes included postoperative gastrointestinal function, including the time to postoperative
first flatus (FFL) and first feces (FFE), and other complications.
Findings
The final analysis included 122 participants. The incidence of preoperative hypokalemia
in the treatment group was significantly lower than that in the control and placebo
groups (50% vs 88.1% vs 77.5%, P < .001). The severity of hypokalemia in the control and placebo groups was greater
than that in the treatment group. No regurgitation or aspiration occurred in the three
groups. No significant differences were observed among the three groups regarding
time to FFL and FFE.
Conclusions
Preoperative carbohydrate drinks containing potassium significantly reduced the incidence
of preoperative hypokalemia and improved preoperative thirst and hunger, but did not
reduce the postoperative time to FFL and FFE or length of hospital stay. However,
as part of the enhanced recovery after surgery protocol, preoperative carbohydrate
drinks containing potassium should be considered, as early as first admittance to
hospital.
Keywords
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Article info
Publication history
Published online: February 01, 2023
Publication stage
In Press Corrected ProofFootnotes
Conflict of Interest: None to report.
Funding: The present study was supported by National Natural Science Foundation of China (No. 81600507) and Natural Science Foundation of Guangdong Province (No. 2016A030313232).
Data Availably Statement: All data generated or analyzed during this study are included in this published article.
Identification
Copyright
© 2022 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.
