Abstract
Purpose
Optimal postoperative pain management remains a significant problem despite the availability
of multiple preoperative, intraoperative, and postoperative pain management interventions.
Recent studies suggest that racialized minorities, female sex, and individuals of
lower socioeconomic status (SES) are more likely to experience more severe pain and
inadequate pain management postoperatively. Our systematic review aimed to determine
race, sex, and SES differences in postoperative pain and postoperative pain management.
Design
This study is a systematic review of literature.
Methods
Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
methodology, we systematically searched 5 databases: Cumulative Index to Nursing and
Allied Health Literature (CINAHL), PubMed, Embase, Scopus, and Cochrane. We included
primary source peer-reviewed articles published after 1990 that measured postoperative
pain and race/ethnicity, sex/gender, or SES, which were published in English. Two
pairs of reviewers independently screened each title, abstract, and article for inclusion.
In cases of disagreement, a third reviewer broke the tie.
Findings
A total of 464 articles were screened, of which 32 were included in this study. In
most studies, Blacks/African American experience more severe postoperative pain than
Whites/Caucasians. Whites were more likely to be prescribed opioids for pain management
than Blacks, Hispanics, and Asians. Also, individuals of lower SES and females reported
more postoperative pain. One study found no race/ethnic group differences in pain
scores and opioid use after the implementation of the enhanced recovery after surgery
(ERAS) protocol.
Conclusion
Optimal postoperative pain relief continues to be a challenge for individuals who
self-identify as racialized minorities, females, and those of lower SES. Standardization
of care may help reduce disparities in postoperative pain management.
Keywords
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References
- Sex differences in the incidence of severe pain events following surgery: a review of 333,000 pain scores.Pain Med. 2014; 15: 1390-1404
- Poorly controlled postoperative pain: prevalence, consequences, and prevention.J Pain Res. 2017; 10: 2287-2298https://doi.org/10.2147/JPR.S144066
- Age and Gender Differences in Pain Management Following Coronary Artery Bypass Surgery.SLACK Incorporated, Thorofare, NJ2000
- Postoperative spine infection: diagnosis and management.Global Spine J. 2018; 8: 37S-43S
- Current issues in postoperative pain management.Eur J Anaesthesiol (EJA). 2016; 33: 160-171
- Racial differences in the pain management of children recovering from anesthesia.Paediatr Anaesth. 2017; 27: 760-767https://doi.org/10.1111/pan.13163
- Racial disparity in the perioperative care for patients undergoing total knee and hip arthroplasty: a retrospective propensity-matched cohort study.J Racial Ethn Health Disparities. 2018; 5: 632-637https://doi.org/10.1007/s40615-017-0409-2
- Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research.The National Academies Press, Washington, DC2011
- Call to action: structural racism as a fundamental driver of health disparities: a presidential advisory from the American Heart Association.Circulation. 2020; 142: e454-e468
- What causes racial health care disparities? A mixed-methods study reveals variability in how health care providers perceive causal attributions.INQUIRY: J Health Care Org, Prov Financ. 2018; 550046958018762840
- Racial differences in prescription of opioid analgesics for chronic noncancer pain in a national sample of veterans.J Pain. 2014; 15: 447-455
- Association between socioeconomic status and pain, function and pain catastrophizing at presentation for total knee arthroplasty.BMC Musculoskeletal Disord. 2015; 16: 1-10
- Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity.J Head Pain. 2017; 18: 1-8
- Perioperative analgesic treatment in Latino and non-Latino pediatric patients.J Health Care Poor Underserved. 2010; 21: 229
- The effect of lower socioeconomic status insurance on outcomes after primary shoulder arthroplasty.J Shoulder Elbow Surg. 2018; 27: S35-S42
- Sex differences in the response to opioids for pain relief: A systematic review and meta-analysis.Pharmacol Res. 2019; 148104447
- Age and preoperative pain are major confounders for sex differences in postoperative pain outcome: A prospective database analysis.PLoS One. 2017; 12e0178659
- The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.BMJ. 2021; 372: n71https://doi.org/10.1136/bmj.n71
- Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement.System Rev. 2015; 4 (Jan 1): 1https://doi.org/10.1186/2046-4053-4-1
- Health Sciences Literature Review Made Easy: The Matrix Method.5th Edition. Jones & Bartlett Learning, Washington, DC2017
- Disparities in TKA outcomes: Census tract data show interactions between race and poverty.Clin Orthopaed Relat Res. 2016; 474: 1986-1995
- Association between race and ethnicity with intraoperative analgesic administration and initial recovery room pain scores in pediatric patients: A single-center study of 21,229 surgeries.J Racial Ethnic Health Disparities. 2021; 8: 547-558
- ERAS protocol to improve racial and ethnic disparities in pain management following cesarean delivery.Am J Obstetrics Gynecol. 2021; 224: S261
- Ethnic differences in analgesic efficacy and safety of liposomal bupivacaine among asian and caucasian surgical patients: A retrospective matched-cohort analysis.Asian J Anesthesiol. 2020; 58: 99-110
- Patient preference and risk assessment in opioid prescribing disparities: a secondary analysis of a randomized clinical trial.JAMA Network Open. 2021; 4 (-e2118801)e2118801
- Ethnic differences in pain perception and patient-controlled analgesia usage for postoperative pain.J Pain. 2008; 9: 849-855
- Associations between socioeconomic status and race with complications after tonsillectomy in children.Otolaryngol–Head Neck Surg. 2014; 151: 1055-1060
- Race and unequal burden of perioperative pain and opioid related adverse effects in children.Pediatrics. 2012; 129: 832-838https://doi.org/10.1542/peds.2011-2607
- Evaluation of racial disparities in postoperative opioid prescription filling after common pediatric surgical procedures.J Pediatr Surg. 2020; 55: 2575-2583
- Ethnic differences in analgesic consumption for postoperative pain.Psychosom Med. 1996; 58: 125-129
- Demographic disparities in the prescription of patient-controlled analgesia for postoperative pain.Acute Pain. 2005; 7: 21-26
- The impact of standard postoperative opioid prescribing guidelines on racial differences in opioid prescribing: a retrospective review.Surgery. 2021; 170: 180-185
- The effect of ethnicity on prescriptions for patient-controlled analgesia for post-operative pain.Pain. 1996; 66: 9-12
- Gender differences in postoperative pain after laparoscopic cholecystectomy.Surg End Other Intervent Tech. 2006; 20: 448-451
- Females with unexplained joint pain following total joint arthroplasty exhibit a higher rate and severity of hypersensitivity to implant metals compared with males: implications of sex-based bioreactivity differences.JBJS. 2017; 99: 621-628
- Sex-and age-related differences in morphine requirements for postoperative pain relief.J Am Soc Anesthesiol. 2005; 103: 156-160
- Gender differences in post-operative pain and patient controlled analgesia use among adolescent surgical patients.Pain. 2004; 109: 481-487
- Sex differences, sleep disturbance and risk of persistent pain associated with groin hernia surgery: a nationwide register-based cohort study.J Pain. 2021; 22: 1360-1370
- Sex differences in negative affect and postoperative pain in patients undergoing total knee arthroplasty.Biol Sex Differences. 2019; 10: 1-8
- Gender differences in postoperative pain, nausea and vomiting after elective laparoscopic cholecystectomy.World J Surg. 2020; 44: 4070-4076
- Hypericum perforatum to improve postoperative pain outcome after monosegmental spinal sequestrectomy (HYPOS): Results of a randomized, double-blind, placebo-controlled trial.J Integr Complement Med. 2022; 28: 407-417
- Sex differences in the daily rhythmicity of morphine consumption after major abdominal surgery.J Opioid Manage. 2017; 13: 85-94
- Gender and pain upon movement are associated with the requirements for postoperative patient-controllediv analgesia: a prospective survey of 2,298 Chinese patients.Can J Anesth. 2002; 49: 249
- Effects of socioeconomic status on patients' outcome after total knee arthroplasty.Int J Qual Health Care. 2008; 20: 40-46
- Socioeconomic status affects the early outcome of total hip replacement.J Bone Joint Surg Br. 2011; 93: 464-469
- Do Socioeconomic disparities exist in postoperative opioid prescription and consumption?.Am Surg. 2020; 86: 1677-1683
- Racial bias in pain assessment and treatment recommendations, and false beliefs about biological differences between blacks and whites.in: 113. 2016: 4296-4301https://doi.org/10.1073/pnas.1516047113
- Racial bias in sport medical staff's perceptions of others’ pain.J Soc Psychol. 2018; 158: 721-729
- Racial bias in pain perception and response: experimental examination of automatic and deliberate processes.J Pain. 2014; 15: 476-484https://doi.org/10.1016/j.jpain.2014.01.488
- Race/ethnicity moderates the association between psychosocial resilience and movement-evoked pain in knee osteoarthritis.ACR Open Rheumatol. 2019; 1: 16-25
- Sex differences in pain responses.Curr Opin Physiol. 2018; 6: 75-81https://doi.org/10.1016/j.cophys.2018.05.006
- Sex Differences in Pain.J Neurosci Res. 2017; 95: 1271-1281https://doi.org/10.1002/jnr.23841
- Studying sex and gender differences in pain and analgesia: a consensus report.Pain. 2007; 132: S26-S45
- An investigation of the effects of testosterone and behavioral expressions of pain on sex/gender differences in pain perception.Psychol Rep. 2019; 122: 826-840
- The influence of menstrual phases on pain modulation in healthy women.J Pain. 2012; 13: 646-655
- Menstrual variation in experimental pain: correlation with gonadal hormones.Neuropsychobiology. 2010; 61: 131-140
- Pain sensations to the cold pressor test in normally menstruating women: comparison with men and relation to menstrual phase and serum sex steroid levels.Am J Physiol-Regul, Integr Comp Physiol. 2007; 293: R1711-R1716
- Age changes in pain perception: a systematic-review and meta-analysis of age effects on pain and tolerance thresholds.Neurosci Biobehav Rev. 2017; 75: 104-113
- Reduced pain inhibition is associated with reduced cognitive inhibition in healthy aging.PAIN. 2014; 155: 494-502
- Effects of a pain catastrophizing induction on sensory testing in women with chronic low back pain: A pilot study.Pain Res Manag. 2017; 20177892494
- Pain catastrophizing moderates relationships between pain intensity and opioid prescription: nonlinear sex differences revealed using a learning health system.Anesthesiology. 2017; 127: 136-146
- Individual variability and sex differences in conditioned pain modulation and the impact of resilience, and conditioning stimulus pain unpleasantness and salience.Pain. 2020; 161: 1847-1860
- Gender Differences in Preoperative opioid use in spine surgery patients: A systematic review and meta-analysis.Pain Med. 2020; 21: 3292-3300
Article info
Publication history
Published online: December 01, 2022
Publication stage
In Press Corrected ProofFootnotes
Conflict of interest: None to report.
Identification
Copyright
© 2022 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.