Abstract
Purpose
This study evaluated and compared the effect of chlordiazepoxide and transcranial
alternating current stimulation (tACS) on changes in blood potassium levels caused
by preoperative anxiety.
Design
This randomized, double-blind placebo control study was performed on 100 patients
undergoing surgery with the American Society of Anesthesiologists physical status
(ASA I) who went through surgery for the first time.
Methods
Patients were classified into four groups of real or sham tACS, chlordiazepoxide,
and placebo. The Amsterdam Preoperative Anxiety information Scale (APAIS) and serum
potassium levels were used to collect data. The results were analyzed using the Kolmogorov-Smirnov
tests, independent t test, Pearson correlation, and χ2 test.
Findings
There was no baseline difference between the groups. A significant difference was
found between real tACS and the chlordiazepoxide group in plasma potassium level (P = .017).
Conclusions
The results showed that real tACS was more effective than chlordiazepoxide in preventing
the decrease of plasma potassium level in the preoperative period. Assessing the efficacy
of the other types of brain electrical interventions is suggested for future studies.
Keywords
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Article info
Publication history
Published online: January 14, 2023
Footnotes
Conflict of Interest: None to report.
Funding: This paper is a part of an MSc thesis supported by Shahid Sadoughi University of Medical Sciences, Iran.
Identification
Copyright
© 2022 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.
