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Review| Volume 38, ISSUE 2, P339-348, April 2023

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Accelerated Perioperative Rehabilitation for Breast Cancer Patients Undergoing Radical Mastectomy: A Systematic Review

  • Author Footnotes
    1 Co-first author
    Su Liu
    Footnotes
    1 Co-first author
    Affiliations
    Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
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  • Author Footnotes
    1 Co-first author
    Yiwei Shen
    Footnotes
    1 Co-first author
    Affiliations
    Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China

    School of Nursing, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
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  • Jialian Xiang
    Affiliations
    Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
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  • Fang Zhou
    Affiliations
    Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
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  • Jian Liu
    Affiliations
    Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
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  • Ningning Zhou
    Affiliations
    Operating Room, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
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  • Lingzhi Cai
    Correspondence
    Address correspondence to: Lingzhi Cai, Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    Affiliations
    Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    Search for articles by this author
  • Author Footnotes
    1 Co-first author
Open AccessPublished:December 01, 2022DOI:https://doi.org/10.1016/j.jopan.2022.06.008

      Abstract

      Purpose

      To summarize and analyze available evidence on perioperative accelerated rehabilitation programs for patients diagnosed with breast cancer that have had a radical mastectomy.

      Design

      This article is a systematic review of literature based on evidence-based methodology.

      Methods

      The ‘6S’ evidence resource pyramid model was used to systematically search a range of databases.

      Findings

      A total of 19 articles were extracted from the literature and used in this study, including 9 clinical decisions, 4 systematic evaluations, 4 expert consensuses, and 2 guidelines. We summarized a total of 47 lines of evidence with regard to various aspects, including preoperative, intraoperative, and postoperative nursing measures.

      Conclusions

      In this systematic review, an evidence-based methodology was used to summarize and analyze the best suggestions for perioperative accelerated rehabilitation nursing programs for breast cancer inpatients undergoing radical mastectomy. We aimed to provide a good reference value and evidence-based guidelines for the continuous improvement and development of nursing practice for the breast cancer patient population.

      Keywords

      Globally, breast cancer is one of the most common forms of malignant tumors in women and accounts for 24% of all new cases of female cancers.
      • Eh A
      • Ah A
      • Ne A
      • et al.
      Global burden and trends in premenopausal and postmenopausal breast cancer: a population-based study.
      Over recent years, the incidence of breast cancer in China has been increasing annually. It is estimated that the annual number of new cases of breast cancer in Chinese women accounts for 19.9% of the total number of new cases of female cancer in China. Breast cancer is now the most common cancer in women and can exert a serious effect on their health.
      • Zhang X
      • Dong X P
      • Guan Y Z
      • et al.
      Research progress on epidemiological trend and risk factors of female breast cancer.
      Although we have made significant progress in treating breast cancer over recent years, modified radical mastectomy is still one of the most commonly used surgical methods for the treatment of breast cancer in China.
      • Si J
      • Guo R
      • Lu X
      • Han C
      • Chen C
      Decision aids on breast
      conserving surgery for early stage breast cancer patients: a systematic review.
      Both breast cancer and surgical trauma do not only cause severe physical stress on the body, but they also have a negative impact on patients in terms of physical defects and self-image.
      Breast cancer and surgery are associated with high treatment costs. When effective rehabilitation training and psychological counseling are not provided promptly, there is a strong likelihood that patients may experience adverse effects (ie, psychological or working life), thus resulting in a significant reduction in their quality of life. A previous study reported the application of accelerated rehabilitation surgery during the perioperative phase of patients undergoing modified radical mastectomy was conducive to reducing opioid consumption, hospital length of stay, and hospitalization costs, while accelerating functional recovery in the limbs following surgery, and improving quality of life.
      • Chiu C
      • Aleshi P
      • Esserman LJ
      • et al.
      Improved analgesia and reduced post-operative nausea and vomiting after implementation of an enhanced recovery after surgery (ERAS) pathway for total mastectomy.
      Enhanced recovery after surgery
      • Evans J
      • Kennedy RH.
      Fundamentals of surgical practice: a preparation guide for the intercollegiate MRCS examination.
      (ERAS) is an evidence-based pathway used with fast-track surgery that standardizes care to minimize postoperative stress and pain, reduce complications, and improve clinical outcomes. The concept of accelerated rehabilitation has been widely used in breast cancer surgery. Despite this, there is still no nursing pathway related to scientific and systematic perioperative accelerated rehabilitation for patients undergoing radical mastectomy for breast cancer.
      This systematic review aimed to summarize and analyze available evidence relating to perioperative accelerated rehabilitation nursing programs for radical mastectomy and provide a standardized reference model for nurses to follow when caring for these patients.

      Data and Methods

      Literature Retrieval Strategy

      The ‘6S’ evidence resource pyramid model
      • Dicenso A
      • Bayley L
      • Haynes RB
      • et al.
      Accessing pre-appraised evidence: fine-tuning the 5S model into a 6S model.
      was used to systematically retrieve appropriate literature. Chinese and international literature databases were searched using the following terms: (‘fast track surgery’ OR ‘ERAS’ OR ‘FTS’ OR ‘fast-track surgery’ OR ‘enhanced recovery after surgery’ OR ‘fast track’) AND (‘breast tumor*’ OR ‘mammary cancer*’ OR ‘mammary carcinoma*’ OR ‘mammary neoplasm*’ OR ‘breast cancer*’ OR ‘cancer’) AND (‘resection’ OR‘surgery’ OR ‘surgical procedure’).
      Guideline databases searched included: Scottish Intercollegiate Guidelines Network (SIGN), National Guideline Clearinghouse (NGC), Registered Nurses' Association of Ontario (RNAO, Canada), Guideline International Network (GIN), National Institute for Health and Clinical Excellence (NICE), National Comprehensive Cancer Network (NCCN, Yimaitong), and China Guideline Network. Additionally, several evidence-based resource databases were searched, including Cochrane Library, Joanna Briggs Institute (JBI) Library, BMJ Best Practice database, and a range of original research databases: Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, Embase, Medline, China National Knowledge Infrastructure (CNKI), Wanfang database, VIP database, and Chinese Biomedical Literature Database. Databases were searched from inception to June 30, 2021.

      Inclusion and Exclusion Criteria

      Inclusion criteria for articles were: (1) target population of an evidence application were perioperative patients with radical mastectomy (aged ≥18 years); (2) use of intervention methods for radical mastectomy for breast cancer under the concept of accelerated rehabilitation perioperative nursing measures; (3) articles related to computer decision support systems, clinical practice guidelines, evidence-based evidence summaries, expert consensus, system evaluations, best practice information manuals, and randomized controlled studies; and (4) written in Chinese or English.
      Articles were excluded for the following reasons: (1) subjects were infants, children, adolescents, having other minor surgical procedures, pregnant and puerperal women, or surgical patients with mental disorders; (2) literature was not relevant to perioperative nursing measures for a radical mastectomy with accelerated rehabilitation; (3) unable to acquire full text of the published article; (4) duplicated articles; and (5) literature including poor quality evaluation.

      Criteria Used to Evaluate the Quality

      We used the AGREE II for guideline quality assessment.
      • Brouwers MC
      • Kho ME
      • Browman GP
      • et al.
      AGREE II: advancing guideline development, reporting and evaluation in health care.
      Systematic evaluations and expert consensus evaluations were assessed using the Australian JBI Evidence-based Health Care Center (2016 edition).
      • Peters M
      • Godfrey C
      • Mcinerney P
      • et al.
      The Joanna Briggs Institute Reviewers’ Manual 2015.
      Randomized controlled trials were evaluated using the corresponding JBI literature quality evaluation tool.
      • Peters M
      • Godfrey C
      • Mcinerney P
      • et al.
      The Joanna Briggs Institute Reviewers’ Manual 2015.
      Evidence summaries and the quality evaluation of clinical decision-making in original articles were evaluated by evidence, according to the type of literature and by guidelines published by the JBI Evidence-based Health Care Center (2016 edition). The literature quality assessment tools used for guidance are recognized as the most appropriate and widely used. Australian JBI Evidence-based Health Care is one of the largest evidence-based collaborating centers in the world,
      • Pearson A
      • Wiechula R
      • Court A
      • et al.
      The JBI model of evidence-based healthcare.
      for other types of literature quality evaluation, the tool corresponding to JBI was selected because it is more specific and operable in the evaluation project compared with the tool proposed by other institutions, and it is easier for the evaluator to obtain relatively consolidated and correct literature quality evaluation results.

      Quality Evaluation Procedures for Studies

      Screening, quality evaluation, and evidence extraction were carried out independently by two clinical nurses. Both had received systematic evidence-based nursing training through completion of nursing quality training courses by the Zhejiang Nursing Association and/or the Joanna Briggs Evidence-based Nursing Cooperation Center. Disagreements between these nurses were resolved by discussion. When evidential conclusions from different sources were contradictory, the inclusion principles were followed to ensure that only high-quality evidence publications were included.

      Findings

      General Characteristics of the Included Literature

      The literature searches yielded 19 articles,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      Chinese experts consensus on perioperative nutritional support in enhanced recovery after surgery (2019 edition)
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      American Society of Anesthesiologists
      Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures an updated report by the American society of anesthesiologists task force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration.
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      including 9 clinical decisions, 4 systematic reviews,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      4 expert consensus papers
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese experts consensus on perioperative nutritional support in enhanced recovery after surgery (2019 edition)
      ,,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      and 2 guidelines
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      American Society of Anesthesiologists
      Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures an updated report by the American society of anesthesiologists task force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration.
      (Table 1). Article extraction followed the steps shown in Figure 1.
      Table 1General Characteristics of the Included Literature
      AuthorsYearDatabase SourceDocument TypeTopic
      CARSE Group
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      2016GlobalExpert consensusPerioperative management of accelerated rehabilitation surgery in China
      Chinese Medical Association Surgery Branch, Chinese Medical Association Anesthesiology Branch
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      2018China Guide NetworkGuidelineChinese expert consensus and path management guide for accelerated rehabilitation surgery
      EEN Branch of Chinese Medical Association
      Chinese experts consensus on perioperative nutritional support in enhanced recovery after surgery (2019 edition)
      2019GlobalExpert consensusChinese expert consensus on accelerating perioperative nutritional support in rehabilitation surgery
      Menaka et al2019Up to DateClinical decision-makingPrevention of venous thromboembolic diseases in adult patients undergoing nonorthopedic surgery
      Daniel et al2019Up to DateClinical decision-makingPerioperative temperature management
      Nadia et al2018Up to DateClinical decision-makingPerioperative blood glucose management of adult diabetic patients
      Girish et al2019Up to DateClinical decision-makingAnesthesia management and the improvement of recovery after significant adult surgery (ERAS)
      Kenneth et al2019Up to DateClinical decisionmakingRisk and prevention of venous thromboembolism in adult cancer patients
      Gregory et al2019Up to DateClinical decision-makingSummary of the causes of venous thrombosis
      Jessica et al2019Up to DateClinical decision-makingPrevention and treatment of postoperative nausea and vomiting
      Deverick et al2019Up to DateClinical decision-makingAntibiotic prevention of surgical site infection in adults
      Edward et al2019Up to DateClinical decision-makingManagement of acute perioperative pain
      International ERAS Association
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      2017PubMedExpert consensusConsensus evaluation of the best perioperative nursing care in breast reconstruction: social suggestions for postoperative recovery period (ERAS)
      American Association of Anesthesiologists
      American Society of Anesthesiologists
      Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures an updated report by the American society of anesthesiologists task force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration.
      2017NICEguidelinePreoperative fasting guidelines
      Lau et al
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      2016PubMedSystem evaluationInfluence of accelerated rehabilitation program on treatment effect and rehabilitation ability of patients
      Offodile et al
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      2019PubMedSystem evaluationSafety and effectiveness of ERAS approach in breast reconstruction
      Mohamad et al
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      2018PubMedSystem evaluationEffect of ERAS on hospital stay and postoperative complications in breast reconstruction
      Johns Hopkins University Microsurgical Breast Reconstruction Team
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      2018PubMedExpert consensusExpert consensus on perioperative ERAS program for breast reconstruction
      Soteropulos et al
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      2019PubMedSystem evaluationSafety of ERAS approach in breast reconstruction
      Figure 1
      Figure 1Inclusion and exclusion results. This figure is available in color online at www.jopan.org.

      Evaluation of the Quality of the Included Literature

      This systematic review of the literature included nine clinical decision articles that were identified as high-quality studies. Four systematic reviews were included.
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      Results of the quality evaluation of these articles are shown in Table 2. Our analysis included four expert consensus articles.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese experts consensus on perioperative nutritional support in enhanced recovery after surgery (2019 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      Results of the quality evaluation of these articles are shown in Table 3. Two guidelines were also included in our findings.
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      American Society of Anesthesiologists
      Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures an updated report by the American society of anesthesiologists task force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration.
      Results of the quality evaluation of these articles are shown in Table 4.
      Table 2Quality Evaluation Outcomes for Systematic Evaluation
      Evaluation ItemLau et al
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      Offodile et al
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      Mohamad et al
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      Soteropulos et al
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      1. Is the evidence-based question clear and definite?YesYesYesYes
      2. Is the standard of literature inclusion appropriate for this evidence-based problem?YesYesYesYes
      3. Is the retrieval strategy appropriate?YesYesYesYes
      4. Is the database or resources for searching literature sufficient?YesYesYesYes
      5. Is the literature quality evaluation standard adopted appropriate?UnclearYesYesUnclear
      6. Whether two or more evaluators independently complete the literature quality evaluation?UnclearYesYesYes
      7. Are certain measures taken to reduce errors when extracting data?UnclearYesYesUnclear
      8. Is the method of combined research appropriate?YesYesYesYes
      9. Has the possibility of publication bias been assessed?YesYesYesNo
      10. Is the proposed policy or practice recommendation based on the results of the systematic evaluation?YesYesYesYes
      11. Is the proposed further research direction appropriate?YesYesYesYes
      Table 3Quality Evaluation Results for Expert Consensus
      Evaluation ItemBranch of Parenteral and Enteral Nutrition of Chinese Medical Association
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      International ERAS Association
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      Microsurgical Breast Reconstruction Team at Johns Hopkins University
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      Expert Group of China Accelerated Rehabilitation Surgery
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      1. Are the sources of opinions marked?UnclearYesYesUnclear
      2. Does the opinion come from influential experts in this field?YesYesYesYes
      3. Does the viewpoint put forward focus on the interests of the people concerned?YesYesYesYes
      4. Are the stated conclusions based on the results of analysis? Is the expression of views logical?YesYesYesYes
      5. Have you consulted other existing literatures?YesYesYesYes
      6. Are there any inconsistencies between the views put forward and the previous literature?YesYesYesYes
      Table 4Quality Evaluation Results for Guidelines
      Information ImportedStandardization Percentage for Each Field (%)Mean Overall Score (points)≥60% of Fields≥30% of FieldsRecommended LevelRecommended?
      Scope and purposeParticipate in personRigidity of formulationClarityApplicabilityIndependence
      Chinese Medical Association Surgery Branch, Chinese Medical Association Anesthesiology Branch
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      84.3550.2542.6789.7552.3824.354.515BYes
      American Association of Anesthesiologists
      American Society of Anesthesiologists
      Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures an updated report by the American society of anesthesiologists task force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration.
      10085.7979.894.5686.4994.347.066AYes

      Summary of Studies

      After determining the quality of the included literature, results were analyzed. If the studies were derived from JBI, we directly adopted the study's classification and recommendation level given by the JBI. For non-JBI evidence, we used an expert consensus method and FAME evaluation principle
      The Joanna Briggs Institute Levels of Evidence and Grades of Recommendation Working Party
      Supporting document for the Joanna Briggs Institute levels of evidence and grades of recommendation.
      to invite 10 experts (including 5 doctors and 5 nurses) from breast specialist wards with ≥10 years’ experience in the field to evaluate the study's feasibility, suitability, clinical significance, and effectiveness. For the consensus process, the two systematic evidence-based nursing trained nurses preclassified the literature using the JBI 2014 evidence classification system. Then, experts were invited to give recommendations based on their professional knowledge and clinical experience. Recommendations were graded as either A (strong) or B (weak).
      Forty-seven topics were identified and included in the analysis for the preoperative, perioperative, intraoperative. and postoperative stages of care. Topics during the preoperative stages focused on: education,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      hospital visits and evaluation,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese experts consensus on perioperative nutritional support in enhanced recovery after surgery (2019 edition)
      ,,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      the cessation of smoking and alcohol use,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      the prevention of venous thrombosis,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,,,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      fasting,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      American Society of Anesthesiologists
      Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures an updated report by the American society of anesthesiologists task force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration.
      ,
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      skin preparation, prophylactic use of antibiotics,,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      and blood glucose control.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      , Topics identified during perioperative stages included: perioperative fluid therapy,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      ,
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      prevention and treatment of vomiting and nausea,,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      and pain management.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      ,
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      Topics identified during intraoperative stages included: anesthesia management,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      management of hypothermia,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      and blood glucose control to prevent venous thrombosis. Topics associated with the postoperative stages included: pulmonary rehabilitation exercise,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      early eating,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      Chinese experts consensus on perioperative nutritional support in enhanced recovery after surgery (2019 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      skin flap monitoring,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      drainage tube (indwelling and removal),
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      incision management,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      early ambulation,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      discharge standards,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      follow-up,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      and health education
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      (Table 5, 6, 7, 8).
      Table 5Summary of Protocol Details for Preoperative Stage
      ClassificationProtocol Details [References]Level of EvidenceRecommendation Level
      Preoperative education•Patients should receive detailed preoperative consultation.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      2A
      •Psychological support should be provided to patients before surgery.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      5A
      Preoperative visit and evaluation•The nutritional status, cardiopulmonary function, and underlying diseases should be comprehensively screened before surgery by multidisciplinary consultation; corrective and targeted treatment should be carried out. Patients should be adjusted to the best state before surgery and carefully evaluated for surgical indications, anesthesia, operative risks and tolerance. Corresponding plans should be formulated for associated diseases and possible complications.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      Chinese experts consensus on perioperative nutritional support in enhanced recovery after surgery (2019 edition)
      ,,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      1A
      Preoperative smoking and alcohol withdrawal•Patients with a history of drinking or smoking should give up drinking for 4 wk, and smoking for at least 2 wk, before surgery.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      Obese patients should be encouraged to lose weight before surgery.
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      5A
      Preoperative prevention of venous thrombosis•The improved Caprini risk assessment model should be used to assess the risk of postoperative VTE in patients before surgery. In the absence of thrombosis prevention, patients receiving surgical treatment should be graded according to the estimated VTE baseline risk (EBR) so as to select appropriate VTE prevention methods and receive education on the risk of VTE.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,,,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      1A
      •The main measures to prevent VTE include early activities, drug treatment, and mechanical methods. Individual VTE prevention strategies should be formulated according to the risk of VTE and the risk and consequences of massive hemorrhage.,1A
      •Mechanical methods for preventing thrombosis include intermittent pneumatic compression (IPC), graded compression stockings (GCS), and venous foot pump (VFP)., , 1A
      •The use of mechanical methods to prevent thrombosis should begin before or in the operating room and continue until discharge., 2A
      •Low molecular weight (LMW) heparin is usually the preferred anticoagulant.2A
      •Thrombosis screening using ultrasound and inferior vena cava filters is not recommended.,2B
      •Prevention of postoperative VTE should avoid the use of inferior vena cava (IVC) filters.2B
      Preoperative fasting•The patients were fasted drink 2 h before surgery and foods 6 h before surgery. They can eat starchy solid foods (the gastric emptying time of dairy products such as milk was equivalent to that of solid foods) before surgery, but fried, fat, and meat foods require a longer fasting time. Carbohydrate-containing drinks can be taken orally before surgery. Patients are usually given 12.5% carbohydrate drinks (800 mL) 10 h before surgery and ≤ 400 mL 2 h before surgery.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      American Society of Anesthesiologists
      Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures an updated report by the American society of anesthesiologists task force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration.
      ,
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      1A
      Skin preparation•Clean the skin of the surgical area with chlorhexidine preoperatively.2A
      •Avoid shaving at planned surgical sites. If skin preparation is necessary, electric shears or a hair removal agent should be used for skin preparation in the surgical area. The skin should be prepared near to the day of surgery.2A
      Preventive use of antibiotics•In the absence of other risk factors for infection, no antibacterial prophylaxis is performed for clean breast surgery. These risk factors include extreme age, poor nutritional status, obesity, diabetes, smoking, co-infection, immunosuppression, corticosteroid treatment, recent surgical procedures, the length of preoperative hospitalization, and known colonization by resistant bacteria.,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      2A
      •Patients with signs of active infection should complete appropriate treatment before surgery, especially when a prosthesis is likely to be fitted. If emergency surgery is considered, the risk of infection must be balanced according to the individual operation time.1A
      •Cefazolin is the preferred antibiotic for prophylaxis. Patients with β-lactam allergy can use clindamycin and vancomycin. No repeated use of antibiotics after wound closure as this may increase resistance to antibiotics .,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      2A
      Preoperative blood glucose control•All patients need careful preoperative medical history and physical examination; some patients need to be further evaluated. Basic laboratory tests should include baseline electrocardiogram (ECG), renal function assessment (serum creatinine), glycosylated hemoglobin, and blood glucose. Perioperative blood glucose control begins before surgery, including the provision of appropriate suggestions for diabetic patients taking hypoglycemic drugs and insulin.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      5A
      •During the whole perioperative period, the perioperative blood glucose levels of diabetic patients and nondiabetic patients were monitored and maintained between 140 and 200 mg/dL (7.8 and 11 mmol/L).5B
      Table 6Summary of Protocol Details for Perioperative Stage
      ClassificationProtocol Details [References]Level of EvidenceRecommendation Level
      Perioperative fluid therapy• The goal-oriented concept of liquid therapy is advocated, and reasonable liquid therapy schemes are formulated and implemented individually according to different therapeutic purposes, disease states, and stages.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      ,
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      1A
      • It is recommended to use balanced crystal solution rather than brine.,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      2B
      • It is recommended that vascular pressors support fluid management and will not have a negative impact on the free flap.5B
      Prevention and treatment of nausea and vomiting during perioperative period• The simplified risk score for postoperative nausea and vomiting created by Apfel et al.
      • Apfel C C
      • Läärä E
      • Koivuranta M
      • et al.
      A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers.
      can be used to assess the risk of postoperative nausea and vomiting in adults before surgery and develop individualized prevention strategies according to the predicted risk degree.
      2B
      • The prevention of postoperative nausea and vomiting in all patients should include multiple modes. The preventive intervention measures include the modification of anesthetics, avoiding general anesthesia, propofol general intravenous anesthesia (TIVA), antiemetic drugs, and acupuncture. Various antiemetic drugs can be used to prevent and treat postoperative nausea and vomiting.,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      2B
      • Promote the use of two antiemetics to reduce postoperative nausea and vomiting.,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      2B
      Perioperative pain management• A postoperative acute pain management team, composed of anesthesiologists, surgeons, nurses, and pharmacists, should be established.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      5B
      • Perioperative pain control using preventive and multimodal analgesia includes nonopioid analgesics, regional anesthesia techniques, local anesthetic wound infiltration, and nondrug analgesia strategies.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      1A
      • Visual analog scale, digital rating scale, and language rating scale should be used to evaluate the pain intensity of patients during rest and exercise in a timely manner. At the same time, the effect of postoperative pain treatment can be evaluated, and adverse reactions such as nausea, vomiting, pruritus and intestinal paralysis should be monitored and actively treated.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      1A
      Table 7Summary of Protocol Details for Intraoperative Stage
      ClassificationProtocol Details [References]Level of EvidenceRecommendation Level
      Anesthesia management• General intravenous anesthesia.
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      1A
      Hypothermia management• The prevention and management of intraoperative hypothermia include preheating before the induction of anesthesia and active intraoperative warming.,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      2A
      • Temperature should be measured during surgery and on arrival in the postanesthesia care unit (PACU), intensive care unit (ICU) or return to the general ward.,2A
      • The patient's body temperature should be routinely monitored during the operation until the surgery is complete. The patient's central body temperature should be maintained at not less than 36° C by means of heating mattresses, pressurized air heating (fan) or circulating water heating systems, transfusion and infusion heating devices.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,,
      2A
      Intraoperative blood glucose control• Intraoperative use of insulin to control blood glucose in patients with breast cancer who also have diabetes is close to normal (< 10 mmol/L), and attention is paid to avoid hypoglycemia.5B
      Intraoperative prevention of venous thrombosis• Thrombosis prevention using 5000 units of subcutaneous heparin 30- 60 min before surgery.5B
      • Intraoperative use of a lower limb compression device to prevent deep venous thrombosis of the lower limb.2B
      Table 8Summary of Protocol Details for Postoperative Stage
      ClassificationProtocol Details [References]Level of EvidenceRecommendation Level
      One-lung rehabilitation exercise• Patients should be encouraged and assisted to experience deep breathing and effective cough as soon as possible after surgery to maintain airway patency.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      5A
      Early eating• Patients should be encouraged to take oral liquid and food as soon as possible, preferably within 24 h after surgery.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      Chinese experts consensus on perioperative nutritional support in enhanced recovery after surgery (2019 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      5A
      Flap monitoring• Routine monitoring of the affected flap should be performed postoperatively, including clinical observation (ie, color, skin temperature and blood supply in the flap area) and the use of equipment. Frequent monitoring is required in the first 72 h. A reasonable monitoring scheme may include monitoring every 24 h, monitoring every 2 h in the next 24 h, and monitoring every 3-4 hours in the next 24 h.
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      2A
      Drainage tube indwelling and removal• The catheter should be avoided or removed as soon as possible. Without special circumstances, the catheter can be removed 1-2 d after operation.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      1A
      • Without a conventional indwelling drainage tube, it is recommended to use an indwelling drainage tube in the case of infection in the surgical wound, poor blood supply in the anastomotic stoma, excessive tension, and other factors that may lead to poor healing.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      5B
      Incision management• The suture removal time should be determined according to age, nutritional status, incision site, and local blood supply.
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      5A
      Early ambulation• Patients should get out of bed within the first 24 h after surgery.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      ,
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      2A
      Discharge standards and follow-up• A quantifiable and operable discharge standard based on patient safety should be formulated, such as the restoration of a semi-liquid diet or oral adjuvant nutritional preparations. There should be no need for intravenous infusion therapy. Oral analgesic drugs can effectively relieve pain. Good wound healing, no signs of infection. Organ function in good condition, free movement. The patient agreed to discharge
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      .
      5A
      • Follow-up and monitoring of patients after discharge should be strengthened, and telephone follow-up and guidance should be routinely conducted within 24-48 h after discharge. Then, 7-10 d after surgery, the patient should return for an outpatient visit, wound suturing, pathological examination results, and to discuss further antitumor treatment.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Offodile AC
      • Gu C
      • Boukovalas S
      • et al.
      Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      2B
      • Clinical follow-up should continue at least until 30 d after surgery.
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      5A
      • Potential complications should be expected and physicians should remain vigilant. A ‘green channel’ should be established to meet the needs of patients for rehospitalization due to complications at any time.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      5A
      Health education• Patients should be instructed not to exercise intensely for 4-6 wk to achieve optimal wound healing and reduce the risk of seroma or contour abnormalities in the donor site.
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      2A

      Discussion

      This systematic review revealed perioperative accelerated rehabilitation measures in the preoperative, perioperative, intraoperative, and postoperative stages. Relevant measures reflected the core idea of accelerated rehabilitation, but also focused on the basic diseases, type of surgery and surgical complications, etc., to improve patient outcomes, and the aim of reasonable utilization of medical resources.

      Preoperative Stage

      In the preoperative stage, findings from this systematic review suggest that medical staff should focus on education,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      hospital visits and evaluation,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      Chinese experts consensus on perioperative nutritional support in enhanced recovery after surgery (2019 edition)
      ,,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      the cessation of smoking and alcohol use,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      the prevention of venous thrombosis,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,,,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      fasting,
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      American Society of Anesthesiologists
      Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures an updated report by the American society of anesthesiologists task force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration.
      ,
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      skin preparation, prophylactic use of antibiotics,,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      and blood glucose control.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      , Findings from studies
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      include recommendations for preoperative stages emphasizing that medical staff should provide patients preoperatively with the relevant knowledge of perioperative regimens to promote rehabilitation by individualized propaganda and education. This is important as it makes patients aware of their critical role in this plan, including early postoperative feeding and early ambulation.
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      It is also essential to provide targeted preoperative psychological support to patients to reduce anxiety, increase cooperation with medical staff, and accept the operation safely.
      Studies
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      Chinese experts consensus on perioperative nutritional support in enhanced recovery after surgery (2019 edition)
      ,,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      emphasizing the core elements of accelerated rehabilitation nursing focused on multidisciplinary collaboration. The patient's physical state can be optimized through multidisciplinary collaboration to respond efficiently to surgery and postoperative functional recovery. A corresponding emergency plan should be formulated according to the patient's situation before surgery to ensure the successful completion of surgery and the complete implementation of postoperative-related treatment measures. Related studies
      • Lee K T
      • Mun G.H.
      Effects of obesity on postoperative complications after breast reconstruction using free muscle-sparing transverse rectus abdominis myocutaneous, deep inferior epigastric perforator, and superficial inferior epigastric artery flap: a systematic review and meta-analysis.
      show smoking, drinking, obesity, and other variables, are some of the factors that can have adverse effects on the results of breast reconstruction surgery. Excessive drinking (drinking five units or more every 5 days or more in the past 30 days) will increase the risk of surgical site infection.
      • Nguyen J A
      • Costa M A
      • Vidar E N
      • et al.
      Effect of immediate reconstruction on postmastectomy surgical site infection.
      Therefore, review findings
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      suggest that patients with a history of drinking or smoking should quit drinking 4 weeks before surgery, and quit smoking 2 weeks before surgery. Weight loss before surgery is also encouraged for obese patients.
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      The expert consensus paper on perioperative accelerated rehabilitation for patients undergoing breast reconstruction published by the ERAS Association
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      proposed that obese patients should reduce weight to less than or equal to 30 kg/m2 before surgery.
      Postoperative venous thrombosis is one of the common postoperative complications of breast cancer patients undergoing radical mastectomy. Postoperative venous thrombosis in patients with breast cancer mainly refers to venous thromboembolism (VTE); this predominantly includes deep venous thrombosis and pulmonary embolism. Compared with nonbreast cancer patients of the same age, the risk of breast cancer patients developing VTE is 3 to 4 times higher.
      • Castaldi M
      • George G
      • Stoller C
      • et al.
      Independent predictors of venous thromboembolism in patients undergoing reconstructive breast cancer surgery.
      The occurrence of postoperative venous thrombosis in breast cancer patients during hospitalization leads to the prolongation of the postoperative recovery process, increasing the medical burden of patients, and causing different degrees of psychological burden to patients and their families. Literature describes
      • Khan U T
      • Walker A J
      • Baig S
      • et al.
      Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis.
      venous thrombosis as a complication that effective measures can prevent. Studies
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,,,,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      predominantly relate to perioperative prevention strategies for venous thrombosis after breast cancer surgery. Risk assessment, patient education, corresponding preventive measures according to the risk level, intervention timing, prevention duration, and intraoperative preventive measures are described, and individualized prevention is advocated according to patients' risk level and related concomitant diseases.
      Studies
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      ,
      • Lin SJ
      Discussion: consensus review of optimal perioperative care in breast reconstruction: enhanced recovery after surgery (ERAS) society recommendations.
      ,
      American Society of Anesthesiologists
      Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures an updated report by the American society of anesthesiologists task force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration.
      ,
      • Sebai ME
      • Siotos C
      • Payne R
      • et al.
      Enhanced recovery
      after surgery pathway for microsurgical breast reconstruction: a systematic review and meta-analysis.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      stipulate patients should fast after 8 p.m. on the day before surgery, although previously, patients were allowed to fast after 10 p.m. in previous clinical practice. However, guidelines for gastrointestinal surgery published by the ERAS Association
      • Feldheiser A
      • Aziz O
      • Baldini G
      • et al.
      Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for anaesthesia practice.
      suggest patients should fast from solid food for 6 hours before surgery and fast from transparent liquid for 2 hours before general anesthesia. A previous study
      • Brady M C
      • Kinn S
      • Stuart P.
      Preoperative fasting for adults to prevent perioperative complications (Review).
      analyzed 22 randomized controlled trials and found that drinking transparent liquid 2 hours before surgery was safe and did not increase the risk of reflux and/or aspiration.
      One study primarily addressed preoperative skin preparation and described procedures used to clean and prepare the skin. Studies have shown the routine preoperative use of disinfectants on the surgical area can reduce the burden of skin flora. Furthermore, the preoperative use of chlorhexidine-based disinfectants for skin cleaning was better than povidone-based cleaning.
      • Privitera GP
      • Costa AL
      • Brusaferro S
      • et al.
      Skin antisepsis with chlorhexidine versus iodine for the prevention of surgical site infection: a systematic review and meta-analysis.
      Therefore, medical staff should be trained to use preoperative chlorhexidine-based disinfectants to clean the skin in the surgical area. A previous meta-analysis reported removing hair from the surgical area with a razor could increase the risk of surgical site infection.
      Preoperative hair removal and surgical site infections: network meta-analysis of randomized controlled trials
      Other studies have shown the use of a razor to prepare the skin was more likely to cut the skin and potentially cause damage by pushing and shearing. Consequently, hair removal cream was suggested as this would not cause damage on the skin surface.
      • Tanner J
      • Norrie P
      • Melen K
      Preoperative hair removal to reduce surgical site infection.
      The timing of skin preparation is also related to the risk of surgical site infection. When the skin is prepared closer to surgery, the incidence of infection at the surgical site is lower.
      • Dellinger E P
      • Hausmann S M
      • Bratzler D W
      • et al.
      Hospitals collaborate to decrease surgical site infections.
      Four studies,
      • Lau CSM
      • Chamberlain RS
      Enhanced recovery after surgery programs improve patient outcomes and recovery: a meta-analysis.
      ,
      • Stone JP
      • Siotos C
      • Sarmiento S
      • et al.
      Implementing our microsurgical breast reconstruction enhanced recovery after surgery pathway: consensus obstacles and recommendations.
      ,
      • Soteropulos CE
      • Tang SYQ
      • Poore SO
      Enhanced recovery after surgery in breast reconstruction: a systematic review.
      addressed the prophylactic use of antibiotics in patients undergoing breast cancer surgery. In the absence of risk factors, preventive measures do not significantly reduce the risk of infection at the surgical site caused by breast plastic or breast mass resection.
      • Gallagher M
      • Jones D J
      • Bell-Syer S V
      Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery.
      A systematic review reported that the preoperative use of antibiotics would reduce the risk of surgical site infection in breast cancer patients undergoing mastectomy or lymph node dissection.
      • Denise Blanchard.
      Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery.
      Therefore, it is necessary to balance the potential risk of surgical site infection with recent signs of active infection when deciding whether to use antibiotics in a prophylactic manner for inpatients.
      Three studies
      Enhanced Recovery after Surgery Expert Group of China
      Chinese experts Consensus on perioperative in enhanced recovery after surgery (2016 edition).
      ,
      Chinese expert consensus and path management guidelines in enhanced recovery after surgery (2018 edition)
      , discussed perioperative blood glucose control . The American Diabetes Association (ADA) approved a target blood glucose range of 80-180 mg/dL (4.4-10 mmol/L) during the perioperative period.
      • Association A D
      Diabetes care in the hospital: standards of medical care in diabetes-2020.
      Other diabetes guidelines recommend target blood glucose levels of noncritical hospitalized patients should be 90-180 mg/dL (5-10 mmol/L).
      • Malcolm J
      • Halperin I
      • Miller D B
      • et al.
      In-hospital management of diabetes.