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Analgesic Effects and Adverse Reactions of Lidocaine for Patient-Controlled Intravenous Analgesia on Patients Undergoing Open Hepatectomy: A Retrospective Analysis

  • Author Footnotes
    † These authors contributed equally to this paper.
    Fei Liu
    Footnotes
    † These authors contributed equally to this paper.
    Affiliations
    Department of Anesthesiology, Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, China
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  • Author Footnotes
    † These authors contributed equally to this paper.
    Liu-Lin Xiong
    Footnotes
    † These authors contributed equally to this paper.
    Affiliations
    Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, China
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  • Ting-Ting Li
    Affiliations
    Department of Anesthesiology, Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, China

    Department of Anesthesiology, West China Tianfu Hospital, Sichuan University, Chengdu, China
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  • Yan-Jun Chen
    Affiliations
    Department of Anesthesiology, Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, China
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  • Wei Ma
    Affiliations
    Department of Anesthesiology, Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, China
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  • Qi-Jun Li
    Affiliations
    Traditional Chinese Medicine, Southwest Medical University, Sichuan University, Luzhou, China
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  • Qian Li
    Correspondence
    Address correspondence to Qian Li, Department of Anesthesiology, West China Hospital, Sichuan University, No. 37 Guoxue lane, Chengdu 610041, China.
    Affiliations
    Department of Anesthesiology, Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, China
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  • Ting-Hua Wang
    Correspondence
    Address correspondence to Ting-hua Wang, Institute of Neurological Disease, West China Hospital, Sichuan University, No. 88 Keyuan South Road, Chengdu 610041, China.
    Affiliations
    Department of Anesthesiology, Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, China
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  • Author Footnotes
    † These authors contributed equally to this paper.
Published:August 18, 2022DOI:https://doi.org/10.1016/j.jopan.2022.05.069

      Abstract

      Purpose

      The aim of this study was to investigate the effect of lidocaine for patient controlled intravenous analgesia (PCIA) in patients who underwent open hepatectomy.

      Design

      A retrospective analysis.

      Methods

      A total of 281 patients who underwent open hepatectomy from July 2018 to December 2018 were included. All patients were assigned into two groups: the lidocaine group (PCIA consisted of lidocaine, sufentanil, tramadol and granisetron) and the control group (PCIA consisted of sufentanil, tramadol and granisetron). The postoperative visual analogue scale (VAS) and complications (including respiratory depression, hypotension, nausea and vomiting, pruritus, numbness of the corners of the mouth, dizziness) between the groups were compared.

      Findings

      There were no significant differences between the characteristics, duration of surgery and anesthesia, and recovery of postoperative activity between the two groups. In the first 3 days after the operation, the postoperative VAS score of the lidocaine group was lower than that of the control group at resting state, while after activity, the postoperative VAS contrast results were completely opposite. In particularly, the resting state at 48 hours (h) (1.05 ± 1.25 vs 1.57 ± 1.54) after surgery and the activity state at 72 h (3.02 ± 1.51 vs 2.2 ± 1.66) after surgery (P < 0.05). The incidence of mouth numbness and dizziness were significantly increased in the lidocaine group (P < 0.05).

      Conclusion

      The addition of lidocaine in PCIA was not beneficial to improve the pain during activities and increased the incidence of perioral numbness and dizziness.

      Keywords

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