Advertisement
Original Article| Volume 33, ISSUE 1, P3-12, February 2018

Intrathecal Morphine–Related Perioperative Hypothermia in Women Undergoing Cesarean Delivery: A Retrospective Case-Control Study

Published:February 13, 2017DOI:https://doi.org/10.1016/j.jopan.2016.04.142

      Purpose

      Rates of inadvertent perioperative hypothermia among women undergoing spinal anesthesia for cesarean delivery are reported to be high. Intrathecal morphine has been noted to have a potentially potent effect on thermoregulation. This retrospective case-control study sought to investigate the incidence of perioperative hypothermia in women undergoing cesarean delivery with and without intrathecal morphine and to describe any clinical factors associated with the condition, the identification of which would provide direction for nursing priorities in the care of the condition.

      Design

      A retrospective case-controlled study design was used.

      Methods

      The charts of 358 women who had undergone emergency or elective cesarean delivery under spinal anesthesia were reviewed: 179 having received intrathecal morphine and 179 having received spinal anesthesia without intrathecal morphine (control group). SPSS (IBM, Armonk, New York), version 22, was used for data analysis, including logistic regression to predict the outcome of hypothermia across the study population.

      Findings

      There was no significant difference (P = .62; 95% confidence interval, −0.09 to 0.15) in mean postoperative temperature for the morphine group (mean postanesthesia care unit arrival temperature, 35.91°C; standard deviation, 0.59) and the no morphine group (mean postanesthesia care unit arrival temperature, 35.88°C; standard deviation, 0.52). However, within groups, the temperature decline preoperatively to postoperatively was statistically (and clinically) significant.

      Conclusions

      The results refute the suggestion that intrathecal morphine contributes to greater core temperature decline in this population; however, it does confirm that perioperative hypothermia is a prevalent concern for women undergoing cesarean delivery and that pre-emptive measures should be routinely considered by health care providers.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of PeriAnesthesia Nursing
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Kurz A.
        • Sessler D.
        • Lenhardt R.
        Preoperative normothermia to reduce the incidence of surgical wound infection and shorten hospitalization.
        N Engl J Med. 1996; 334: 1209-1215
        • Beilin B.
        • Shavit Y.
        • Razumovsky J.
        • Wolloch Y.
        • Zeidel A.
        • Bessler H.
        Effects of mild perioperative hypothermia on cellular immune responses.
        Anesthesiology. 1998; 89: 1133-1140
        • Scott E.M.
        • Buckland R.
        A systematic review of intraoperative warming to prevent postoperative complications.
        AORN J. 2006; 83: 1090-1113
        • Leslie K.
        • Sessler D.I.
        • Bjorksten A.R.
        • Moayeri A.
        Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium.
        Anesth Analg. 1995; 80: 1007-1014
      1. National Collaborating Centre for Nursing and Supportive Care, Clinical Practice Guideline. The Management of Inadvertent Perioperative Hypothermia in Adults. NICE Clinical Guidelines, No. 65, London, UK: National Institute for Health and Clinical Excellence.

        • Reynolds L.
        • Beckmann J.
        • Kurz A.
        Perioperative complications of hypothermia.
        Best Pract Res Clin Anaesthesiol. 2008; 22: 645-657
        • Hess P.E.
        • Snowman C.E.
        • Wang J.
        Hypothermia after cesarean delivery and its reversal with lorazepam.
        Int J Obstet Anesth. 2005; 14: 279-283
        • Wishaw K.
        Hypothermia associated with subarachnoid morphine.
        Anaesth Intensive Care. 1997; 25: 586
        • Hui C.K.
        • Huang C.H.
        • Lin C.J.
        • Lau H.P.
        • Chan W.H.
        • Yeh H.M.
        A randomised double-blind controlled study evaluating the hypothermic effect of 150 microg morphine during spinal anaesthesia for Caesarean section.
        Anaesth Intensive Care. 2006; 61: 29-31
        • Sayyid S.S.
        • Jabbour D.G.
        • Baraka A.S.
        Hypothermia and excessive sweating following intrathecal morphine in a parturient undergoing cesarean delivery.
        Reg Anesth Pain Med. 2003; 28: 140-143
        • Kavee E.H.
        • Ramanathan S.
        • Bernstein J.
        • Zakowski M.I.
        The hypothermic action of epidural and subarachnoid morphine in parturients.
        Reg Anesth. 1991; 16: 325-328
        • Kosai K.
        • Takasaki M.
        • Kawasaki H.
        • Nagata N.
        Hypothermia associated with intrathecal morphine.
        J Anesth. 1992; 6: 349-352
        • Ryan K.F.
        • Price J.W.
        • Warriner C.B.
        • Choi P.T.
        Persistent hypothermia after intrathecal morphine: Case report and literature review.
        Can J Anaesth. 2012; 59: 384-388
        • Bicalho G.P.
        • Viana Castro C.H.
        • Cunha Cruvinel M.G.
        • Bessa Jr., R.C.
        Sudorese profusa e hipotermia após administração de morfina por via subaracnóidea Relato de caso.
        Rev Bras Anestesiol. 2006; 56 ([in Portugese]): 52-56
        • Kanazawa S.
        • Okutani R.
        Hypothermia after accidental intrathecal administration of high-dose morphine.
        Circ Contr. 2015; 36: 25-27
        • Giladi Y.
        • Ioscovich A.
        Hypothermia following intrathecal morphine injection during cesarean section: A case report and literature review.
        J Anesth Clin Res. 2015; 6: 527
        • Butwick A.J.
        • Lipman S.S.
        • Carvalho B.
        Intraoperative forced air-warming during cesarean delivery under spinal anesthesia does not prevent maternal hypothermia.
        Anesth Analg. 2007; 5: 1413-1419
        • Horn E.P.
        • Schroeder F.
        • Gottschalk A.
        • et al.
        Active warming during cesarean delivery.
        Anesth Analg. 2002; 94: 409-414
        • Buggy D.J.
        • Crossley A.W.
        Thermoregulation, mild perioperative hypothermia and postanaesthetic shivering.
        Br J Anaesth. 2000; 84: 615-628
        • Munday J.
        • Hines S.
        • Wallace K.
        • Chang A.
        • Gibbons K.
        • Yates P.
        A systematic review of the effectiveness of warming interventions for women undergoing caesarean section.
        Worldviews Evid Based Nurs. 2014; 11: 383-393
        • Fallis W.M.
        • Hamelin K.
        • Symonds J.
        • Wang X.
        Maternal and newborn outcomes related to maternal warming during cesarean delivery.
        J Obstet Gynecol Neonatal Nurs. 2006; 35: 324-331
        • Halloran O.J.
        Warming our Cesarean section patients: Why and how?.
        J Clin Anesth. 2009; 21: 239-241
        • Covidien
        Genius 2 Tympanic Thermometer Operating Manual.
        Covidien, Mansfield, MA2011
        • Peduzzi P.
        • Concato J.
        • Kemper E.
        • Holford T.R.
        • Feinstein A.
        A simulation study of the number of events per variable in logistic regression analysis.
        J Clin Epidemiol. 1996; 49: 1373-1379
        • Bamgbade O.
        Perioperative temperature management in day-case surgical patients.
        Eur J Anaesthesiol. 2012; 29: 354-355
        • Hooper V.D.
        • Chard R.
        • Clifford T.
        • et al.
        ASPAN's evidence-based clinical practice guideline for the promotion of perioperative normothermia: Second edition.
        J Perianesth Nurs. 2010; 25: 346-365
        • Torossian A.
        Thermal management during anaesthesia and thermoregulation standards for the prevention of inadvertent perioperative hypothermia.
        Best Pract Res Clin Anaesthesiol. 2008; 22: 659-668
        • Woolnough M.J.
        • Hemingway C.
        • Allam J.
        • Cox M.
        • Yentis S.M.
        Warming of patients during caesarean section: A telephone survey.
        Anaesthesia. 2009; 64: 50-53
        • Sultan P.
        • Habib A.S.
        • Cho Y.
        • Carvalho B.
        The effect of patient warming during caesarean delivery on maternal and neonatal outcomes: A meta-analysis.
        Br J Anaesth. 2015; 115: 500-510
        • Frank S.
        • Beattie C.
        • Christopherson R.
        • et al.
        Epidural versus general anesthesia, ambient operating room temperature, and patient age as predictors of inadvertent hypothermia.
        Anesthesiology. 1992; 77: 252-257

      Biography

      Judy Munday, BA (Hons), DipEd (Nurs), RN, Registered Nurse, Post-Anaesthetic Care Unit, Mater Health Services, Brisbane, Queensland, Australia; Queensland University of Technology, Brisbane, Queensland, Australia

      Biography

      Sonya Osborne, PhD, RN, Senior Lecturer, School of Nursing Queensland University of Technology, Brisbane, Queensland, Australia

      Biography

      Patsy Yates, PhD, DipAppSci, MSocSci, RN, FACN, FAAN, Professor/Head of School, School of Nursing Queensland University of Technology, Brisbane, Queensland, Australia