Few studies have investigated the anti-inflammatory properties of ellagic acid and
no published studies have examined the effects of ellagic acid in combination with
anesthetic adjuvants. In this study, 54 Sprague-Dawley rats were assigned to one of
six groups: (1) vehicle; (2) ketorolac and vehicle; (3) meloxicam and vehicle; (4)
ellagic acid and vehicle; (5) ellagic acid, ketorolac, and vehicle; and (6) ellagic
acid, meloxicam, and vehicle. Groups 5 and 6 investigated interactions between ellagic
acid and cyclooxygenase inhibitors. Paw inflammation was induced with 3% carrageenan
and was measured with a plethysmometer at 30 minutes and 4, 8, and 24 hours after
intraperitoneal injection. All rats received one intraperitoneal injection of equivalent
volumes according to group assignment. Analysis of covariance followed by post hoc
analysis determined that ketorolac was the only compound to significantly reduce paw
edema at 4 hours (P = .019); ellagic acid alone (P = .038) and the combination of ellagic acid and ketorolac (P = .038) were the only compounds to significantly reduce paw edema at 8 hours. At
24 hours, only ellagic acid was effective (P = .01). Our findings suggest that ellagic acid may be effective against inflammation,
may have a prolonged onset and duration of action, and may interact with known cyclooxygenase
inhibitors.
Keywords
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References
- Trends in alternative medicine use in the United States, 1990-1997: Results of a follow-up national survey.JAMA. 1998; 280: 1569-1575
- Trends in use of complementary and alternative medicine by US adults: 1997-2002.Altern Ther Health Med. 2005; 11: 42-49
- Dietary supplement use in U.S. Army Special Operations candidates.Mil Med. 1999; 164: 495-501
- A national survey of certified registered nurse anesthetists’ knowledge, beliefs, and assessment of herbal supplements in the anesthesia setting.AANA J. 2005; 73: 368-377
- Herbal medicine use by children presenting for ambulatory anesthesia and surgery.Paediatr Anaesth. 2004; 14: 916-919
- The effects of valerian on the time course of emergence from general anesthesia in Sprague-Dawley rats (Rattus norvegicus).AANA J. 2007; 75: 431-435
- Effect of St. John’s wort on drug metabolism by induction of cytochrome P450 3A4 enzyme.JAMA. 2003; 290: 1500-1504
- Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: A randomized, placebo-controlled, double-blind, crossover study.Int J Impot Res. 2007; 19: 564-567
- Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease.Am J Cardiol. 2009; 104: 936-942
- Nutraceuticals and prostate cancer prevention: A current review.Nat Rev Urol. 2010; 7: 21-30
Murr A. A winning equation. Available at: http://www.newsweek.com/id/46250. Accessed April 2, 2010.
- Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice.Int J Cancer. 2005; 113: 423-433
- Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid.J Pharm Pharmacol. 2006; 58: 1265-1273
- Analgesic-antipyretic and anti-inflammatory agents; pharmocotherapy of gout; pharmacotherapy of gout.in: Bruton L. Parker K. Goodman and Gillman’s The Pharmacological Basis of Therapeutics. 11th ed. McGraw-Hill, New York2010: 683-723
- Investigation of the antihyperalgesic effects of the pomegranate extract ellagic acid.AANA J. 2008; 76: 365-366
- Analgesic effectiveness of ketorolac compared to meperidine in the rat formalin test.Anesth Prog. 1997; 44: 11-16
- Evaluation of pharmacological profile of meloxicam as an anti-inflammatory agent, with particular reference to its relative selectivity for cyclooxygenase-2 over cyclooxygenase-1.Pharmacology. 1997; 55: 44-53
- Inhibition of cyclo-oxigenase-2 activity does not abolish the anabolic effect of prostaglandin E2 in vivo or in vitro.J Endocrinol. 2002; 174: 127-135
- Enhancement of radiation-induced oxidative stress and cytotoxicity in tumor cells by ellagic acid.Clin Chim Acta. 2005; 359: 89-100
- Antiinflammatory and analgesic effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rats and mice.Methods Find Exp Clin Pharmacol. 2006; 28: 441-446
- Free radical scavengers, anti-inflammatory and analgesic activity of Acaena magellanica.J Pharm Pharmacol. 2002; 54: 835-844
- Distribution and metabolism of ellagic acid in the mouse following intraperitoneal administration.Cancer Lett. 1987; 34: 165-171
- Comparison of mouse and rat cytochrome P450-mediated metabolism in liver and intestine.Drug Metab Dispos. 2006; 34: 1047-1054
- Assessing transient and persistent pain in animals.in: Textbook of Pain. 4th ed. Churchill-Livingstone, Edinburgh1999: 359-369
- The effect of a sciatic nerve block on the development of inflammation in carrageenan injected rats.Anesth Analg. 1999; 89: 979-984
- Disposition of the plant phenol ellagic acid in the mouse following oral administration by gavage.Xenobiotica. 1988; 18: 397-405
Biography
Stephanie Corbett, MSN, CRNA, is a staff nurse anesthetist at the VA San Diego Medical Center, San Diego, CA.
Biography
Janice Daniel, MSN, CRNA, CPT, is a staff CRNA at Will Army Community Hospital, FT Stewart, GA.
Biography
Rachael Drayton, MSN, CRNA, CPT, is a staff CRNA at Will Army Community Hospital, FT Stewart, GA.
Biography
Melanie Field, MSN, CRNA, is a staff CRNA at the Manhattan Campus of the VA NY Harbor Healthcare System, New York, NY.
Biography
Rebecca Steinhardt, MSN, CRNA, is a staff CRNA at the Robert J. Dole VA Medical Center, Wichita, KS.
Biography
Normalynn Garrett, COL(R), PhD, CRNA, is the Project Director/CRNA for the Geneva Foundation, San Antonio, TX.
Article info
Footnotes
This study was funded by the American Association of Nurse Anesthetists Foundation.
Identification
Copyright
© 2010 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.
