Journal of PeriAnesthesia Nursing
Volume 23, Issue 2 , Pages 111-121 , April 2008

Lipid Emulsion as Rescue for Local Anesthetic-Related Cardiotoxicity

  • Mary K. Clark, MA, FNP, B-C

      Affiliations

    • Corresponding Author InformationAddress correspondence to Mary K. Clark, MA, FNP, B-C, Milstein Hospital Room 4-446, Department of Anesthesiology, Columbia University Medical Center, 622 168th St, New York, NY 10032

References 

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  2. Renehan EM, Kayser Enneking F, Varshney M, et al. Scavenging nanoparticles: An emerging treatment for local anesthetic toxicity. Reg Anesth Pain Med. 2005;30:380–384
  3. Salomaki TE, Laurila PA, Ville J. Successful resuscitation after cardiovascular collapse following accidental intravenous infusion of levobupivacaine during general anesthesia. Anesthesiology. 2005;103:1095–1096
  4. Klein SM, Pierce T, Rubin Y, et al. Successful resuscitation after ropivacaine-induced ventricular fibrillation. Anesth Analg. 2003;97:901–903
  5. Litz RJ, Popp M, Stehr SN, et al. Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia. 2006;61:800–801
  6. Rosenblatt MA, Abel M, Fischer GW, et al. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology. 2006;105:217–218
  7. Foxall G, McCahon R, Lamb J, et al. Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid®. Anaesthesia. 2007;62:516–518
  8. Corcoran W, Butterworth J, Weller RS, et al. Local anesthetic-induced cardiac toxicity: A survey of contemporary practice strategies among academic anesthesiology departments. Anesth Analg. 2006;103:1322–1326
  9. Stoelting RK, Hillier SC. Local anesthetics. In: Pharmacology and Physiology in Anesthetic Practice. Philadelphia: Lippincott Williams & Wilkins; 2006;p. 179–207
  10. Jin P, Min JC. Local anesthetics. In:  Dunn PF,  Alston RA,  Baker KH, et al. editor. Clinical Anesthesia Procedures of the Massachusetts General Hospital. 7th ed.. New York: Lippincott Williams & Wilkins; 2007;p. 238–246
  11. Weinberg GL. Current concepts in resuscitation of patients with local anesthetic cardiac toxicity. Reg Anesth Pain Med. 2002;27:568–575
  12. Pasvankas GW, Sidhu DS. Regional anesthesia. In:  Dunn PF,  Alston RA,  Baker KH, et al. editor. Clinical Anesthesia Procedures of the Massachusetts General Hospital. 6th ed.. New York: Lippincott Williams & Wilkins; 2007;p. 273–304
  13. Borgeat A, Ekatodrami G, Blumenthal S. Interscalene brachial plexus anesthesia with ropivacaine 5 mg/ml and bupivacaine 5 mg/ml: Effects on electrocardiogram. Reg Anesth Pain Med. 2004;29:557–563
  14. Nishida T, Pian-Smith M. Spinal, epidural and caudal anesthesia. In:  Dunn PF,  Alston RA,  Baker KH, et al. editor. Clinical Anesthesia Procedures of the Massachusetts General Hospital. 6th ed.. New York: Lippincott Williams & Wilkins; 2007;p. 247–272
  15. Weinberg G, Paisanthasan C, Feinstin D. The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation. Anesth Analg. 2004;98:790–795
  16. Weinberg GL, VadeBoncouer T, Ramaraju GA. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology. 1998;88:1071–1075
  17. Weinberg G, Ripper R, Feinstein DL, et al. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med. 2003;28:198–202
  18. Weinberg G, Ripper R, Murphy P. Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine in the isolated rat heart. Reg Anesth Pain Med. 2006;31:296–303
  19. Greensmith JE, Murray WB. Complications of regional anesthesia. Curr Opin Anaesthesiol. 2006;19:531–537
  20. Weinberg G. Instruction labels for use of lipid emulsion. Available at: http://www.lipidrescue.org. Accessed June 22, 2007.
  21. In:  Field JM,  Hazinski MF,  Gilmore D editor. Handbook of Emergency Cardiovascular Care for Healthcare Providers. Chicago, IL: American Heart Association; 2006;
  22. Groban L, Butterworth J. Lipid reversal of bupivacaine toxicity: Has the silver bullet been identified?. Reg Anesth Pain Med. 2003;28:167–169

PII: S1089-9472(08)00006-3

doi: 10.1016/j.jopan.2008.01.005

Journal of PeriAnesthesia Nursing
Volume 23, Issue 2 , Pages 111-121 , April 2008

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